The acute toxicity and efficacy of Psidium guajava leaves water extract on Salmonella
typhi infected wistar rats had been studied. Oral administration of 10–50 mg/100 g of the
extract showed no significant harmful effect in the animals after 72 h. The administration
of 10-30 mg/100 g of the extract 12 h through the same route to rats infected with
Salmonella typhi produced a recovery within seven days. The Salmonella infection
equally responded to chloramphenicol, a conventional antibiotic used in the treatment of
this infection. These results suggested that the water extract of Psidium guajava leave
was non toxic at the tested doses and effective against Salmonella infection in wistar rats.