Cyclosporine is being used as an immunosuppressive agent in transplant recipients for more than fifteen years and has been reported to cause various toxic manifestations in such patients. A study was carried out on sixty indigenous renal transplant recipients on cyclosporine therapy to assess the drug toxicity. The patient population was divided into three groups depending upon the dose and blood cyclosporine levels. The parameters used to assess the toxicity included renal and liver functions tests, serum lipids levels, gum hyperplasia , hypertension and skin changes. A significant and gradual decrease in toxicity was recorded with an increase in post transplant period in patients of all groups (P<0.001). The results showed that cyclosporine can be used for long term in renal transplant recipients as an essential part of their management without evidences of progressive toxic nephropathy.
B. S. Shagufta , A. K. Farooq , M. M. Ahmed , S. D. Sajid and K. Faiza , 2000. Adverse Effects of Cyclosporine Therapy in Renal Transplant Recipients . Pakistan Journal of Biological Sciences, 3: 1733-1735.