In the present study Acacia catechu-Catechin (CTN) was evaluated for
antiamnesic and antioxidant activity using various in vivo models. Scopolamine
and natural aging were used to induce experimental amnesia in mice. The tested
does of CTN (40, 20 and 10 mg kg-1) significantly enhanced the learning
capacity and retention of memory in Passive Shock Avoidance and Spatial Water
cage exteroceptive behavioural models. Pre-treatment with CTN restored the increased
levels of lipid peroxidation and reduced glutathione due to scopolamine and
natural aging. A dose dependent CTN (40, 20 and 10 mg kg-1) antioxidant
activity of Thiobarbituric acid reactive substances (TBARS) and reduced glutathione
(GSH) in whole brain was seen, which were comparable to Standard Piracetam (400
mg kg-1). Hence, it is worthwhile to explore the potential of this
Acacia catechu-Catechin in the management of Neurodegenerative disorders
of the type Alzheimers disease.
S.M. Biradar, K.C. Tarak, V.H. Kulkarni, P.V. Habbu and D.M. Smita, 2012. Antiamnesic and Antioxidant Effect of Acacia catechu-catechin in Normal, Aged and Scopolamine Challenged Cognitive Deficit Mice. Journal of Pharmacology and Toxicology, 7: 231-241.