Abstract:
The present investigation aims at assessing the antiaflatoxigenic
effect of aqueous extracts of some traditional medicinal plants (namely,
Zingiber officinale Roscoe rhizome, Cinnamomum zeylanicum
bark, Trigonella foenum graecum seeds, Camellia sinensis
leaves and Salvia officinalis leaves) compared to the anticancer
drug, methotrexate (MTX) against aflatoxin-B1 (AFB1) induced renal and
cardiac damage in rats. The results revealed that administration of AFB1
induces oxidative stress in kidneys of AFB1-treated rats through elevating
the level of malondialdehyde (MDA) and depleting the levels of tissue
antioxidants, glutathione reductase (GR), glucose-6-phosphate dehydrogenase
(G-6-PDH) and vitamin C. The results also showed that aflatoxicosis interfere
with the cellular energy supply of rat hearts through its inhibitory action
on some markers of energy metabolism indicated by a decrease in glucose
and glycogen contents of heart and a reduction in the activities of some
glycolytic enzymes, phosphogluco-isomerase (PGI), glyceraldehyde-3-phosphate
dehydrogenase (GAPDH) and lactate dehydrogenase (LDH) compared to normal
healthy animals. Supplementation of the aqueous extracts of the above
mentioned plants, effectively ameliorated the deviation induced in both
kidneys and hearts of animals in response to AFB1 administration. This
effect was evident through reducing MDA level and releasing the inhibitory
effect of AFB1 on the levels of antioxidants in kidneys as well as on
the energetic biomarkers in hearts. However, administration of MTX to
AFB1-treated rats dramatically amplified the toxic effect of aflatoxicosis
induced in both kidneys and hearts, indicated by marked increment in MDA
level and decrease in the levels of antioxidants in kidneys of AFB1- MTX
group in relation to AFB1-group, also a marked decrease in the bioenergetic
markers in hearts of AFB1- MTX treated animals versus AFB1-treated ones
was documented. From the current investigation, it can be concluded that
supplementation of the extracts of the different plants presented in this
study was beneficial in modulating the alterations induced in kidneys
and hearts of rats under the effect of AFB1.
|
Subscribe Today 
