Abstract:
The effect of gasoline vapours (17.8±2.6 cm3/h/m3/day)
on renal functions was assessed from the total kidney weights and the
levels of serum creatinine, urea and blood urea nitrogen (BUN) in male
and female rats, following 64 days of exposure. The results showed an
insignificant (p>0.05) increase in percentage kidney weight per total
body weight (PKW/BW), decrease in total serum protein and a significant
increase (p<0.05) in serum creatinine, urea and BUN levels in both
male and female test rats, compared respectively with the control. However,
the percentage changes in the PKW/BW, serum creatinine and urea levels
obtained for female rats were observed to be significantly higher (p<0.05),
compared to the respective percentage changes obtained for male rats.
This observation indicates that frequent exposure to gasoline vapours
may cause renal dysfunction in rats, with females at greater risk.
F.E. Uboh, M.I. Akpanabiatu and Y. Alozie, 2008. Comparative Effect of Gasoline Vapours on Renal Functions in Male
and Female Albino Wistar Rats. Journal of Pharmacology and Toxicology, 3: 478-484.
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