The ethanolic leaf extract of Eremomastax speciosa was evaluated for antimicrobial and antianaemic activities. The crude ethanolic extract, as well as n-hexane and acqueous fractions were tested against pure clinical cultures of Staphylococcus aureus, E. coli, Candida albicans and Aspergillus niger. The acqueous fraction showed a higher activity against all tested organisms except A.niger. This was followed by n-hexane fraction which showed a broad activity against all tested organisms. The crude extract was only active against E. coli and Staph. aureus. The ethanolic crude extract (500-2000 mg kg-1) also demonstrated antianaemic property by significantly (p< 0.01) elevating Red blood cell counts, packed cell volume, Haemoglobin concentration and white blood cell counts of rats treated with it. These findings justify the ethnomedical use of this plant.