Abstract:
Pearl millet 1 g/kg day, potassium iodate 50 ppm, and the two combined were fed to male Nubian goats for periods up to 111 days. There was no evidence of any carcinogenic effect of Pearl millet on the thyroid gland or other vital organs, but the main features were goiter and entero-hepatonephropathy. In male goats, dietary potassium iodate was neither toxic nor protective against goiter. Severe damage to the thyroid follicles associated with prominent alopecia, nervous signs and exophthalmia were correlated with changes in serum AST, GGT and ALP activities and total protein, albumin, globulin, total lipid, cholesterol, creatinine, calcium, inorganic phosphate, magnesium, iodine and selenium concentrations and with alteration in thyroid, liver, kidneys, heart, spleen and semi-membranous muscles iodine and selenium levels and in hematology.
Warda S. Abdel Gadir and S.E.I. Adam, 2007. Effect of Feeding Pearl Millet (Pennisetum typhoides), Potassium Iodate or Their Mixture to Nubian Goats. Journal of Pharmacology and Toxicology, 2: 183-189.
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