Treatment non-adherence for chronic illnesses such as diabetes is a common
problem. The aim of the study was to assess the pattern of non-adherence to
diabetic therapy and associated factors among type 2 diabetic patients. A cross
sectional study was conducted from February 01 to April 30, 2011, at Jimma University
Specialized Hospital diabetic clinic. Data on Socio-demographic characteristics,
disease related and medication related factors, complexity of regimen and drug
side effects were collected. Medication non-adherence was measured using a self-reported
4-item Morisky scale. Patient characteristics, number and dosing of all prescribed
medications, glycemic control levels, diabetes related complications, co-morbid
conditions and diabetes related admissions were reviewed from patient records.
Univariate and multivariate logistic regression model was used to identify the
factors related to non-adherence. Among the total of 267 type 2 diabetic patients
(mean age 52.4±11.9), the prevalence of non-adherence was 24.3% (n =
267). About half of the patients 140 (52.4%) were on Metformin/Glibenclamide
based combination therapy. Patients with depressive symptoms (AOR = 2.404, 95%
CI = 1.323-4.366, p = 0.004) and who experienced side effects (AOR = 1.868,
95% CI = 1.012-3.446, p = 0.046) were twice more likely to be non adherent than
without depressive symptoms and without manifesting side effects, respectively.
Similarly, diabetic patients on complex regimen were three times non adherent
(AOR = 3.413, 95% CI = 1.652-7.050, p = 0.001) than those with simple regimen.
In conclusion, non-adherence in the current study was high particularly among
patients with depressive symptoms, side effects and on complex regimen. Thus,
continuous adherence monitoring and support services need to be implemented
to such group of patients.
Gebrehiwot Teklay, Jemal Hussien and Dawit Tesfaye, 2013. Non-adherence and Associated Factors among Type 2 Diabetic Patients at Jimma University Specialized Hospital, Southwest Ethiopia. Journal of Medical Sciences, 13: 578-584.