The present study was designed to investigate the effects of buspirone (a partial 5-HT 1A receptor agonist) and 8-hydroxy-2-(di-n-propylamino) tetraline (8-OH-DPAT, a full 5-HT 1A receptor agonist) on restraint-induced behavioral deficits. Exposure to a single episode of 2 h restraint stress decreased food intake, growth rate and elicited anxiogenic like behavior in rats. Prior administration of buspirone and 8-OH-DPAT attenuated stress-induced behavioral deficits of food intake and exploratory activity in a light-dark box. Novelty-induced anxiety in unrestrained animals was also diminished by prior administration of 8-OH-DPAT but not buspirone. The effects on the attenuation of restraint-induced anorexia were greater in 8-OH-DPAT than buspirone injected animals. The results are discussed in the context of a role of somatodendritic as well as postsynaptic 5-HT 1A receptors in the attenuation of restraint-induced behavioral deficits.
Noreen Samad , Tahira Parveen , Saida Haider and Darakhshan Jabeen Haleem , 2005. Attenuation of Restraint-induced Anorexia and Anxiogenic Behavior by Serotonin-1A Agonists in Rats. Journal of Medical Sciences, 5: 289-293.