Application of rifamycin as a broad spectrum antibiotic, due to its demand and high consumption is increasing in human therapy. Continuous efforts are being made to produce it in a cheaper way using different available raw materials. In the present study, agroindustrial residual products like cereal bran were screened for the production of rifamycin SV with Amycolatopsis mediterranei by solid state fermentation. Optimization of various cultural and physiological parameters using cereal bran was carried out in conventional method by one parameter at a time method. The results indicated that at 90% initial moisture level and optimum cultural conditions, the production of rifamycin SV was higher with finger millet bran as substrate and showed a yield of 246 mg/100 gds while using glucose as a carbon source. This study confirms that cereal bran can perform as well solid substrate comprising of available nutrients along with a suitable carbon source for various antibiotic and metabolite fermentations thereby decreasing the production costs.
A. Manikyam, Shaik Naseeruddin, L. Sateesh, S. Venkateshwar and L. Venkateswar Rao, 2012. Rifamycin SV Production Using Cereal Bran as Solid Substrate with Amycolatopsis mediterranei. Research Journal of Microbiology, 7: 227-234.