Abstract:
The potential for a sodium silicate complex (SSC) to reduce Post-harvest contamination
of foods and water was evaluated in antibacterial activity assays against four
Gram positive, Gram negative and clinically isolated multidrug resistant strains
of bacteria. SSC inhibited the growth of all bacterial strains and the Minimal
inhibitory Concentration (MIC90) was in the range of 21.3-26.6 μg
mL-1 for Gram negative bacteria, 10.6-53.2 μg mL-1
for Gram positive bacteria and 42.5-212.7 μg mL-1 the antibiotic
resistant strains. Additionally, the Lethal Dose (LD50) for acute
oral toxicity of SSC determined in Female Albino Sprague-Dawley rats by oral
gavaging was found to be >5000 mg kg-1, Results suggest potential
pharmaceutical, food safety and water quality application of SSC and merits
further investigation.
D.A. Vattem, V. Maitin and C.R. Richardson, 2012. Evaluation of Antibacterial and Toxicological Effects of a Novel Sodium Silicate Complex. Research Journal of Microbiology, 7: 191-198.
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