A Modified solid-state fermentation was used to produce mevastatin by Penicillium citrinum NCIM 768 using wheat bran as carrier in glycerol and urea based medium as moistening agents. Initially maize, rice, wheat, barley, wheat bran were compared as carrier. Wheat bran was the most suitable carrier, as it did not show agglomeration during fermentation process resulting in better heat and mass transfer during fermentation and higher product yields. The best combination of physiochemical parameters during fermentation process was found to be 28°C incubation temperature, 4.5 medium pH, 20 g of wheat bran of particle size 0.701-1.0 mm at a inoculum volume 2 mL, after 144 h of incubation in a humidity chamber of 70% relative humidity resulted in mevastatin yield of 0.0554 mg mL-1 in fermentation broth.
M. ZafferAhamad, Bibhu Prasad Panda , Saleem Javed and Mohd. Ali , 2006. Production of Mevastatin by Solid-State Fermentation Using Wheat Bran as Substrate. Research Journal of Microbiology, 1: 443-447.