In the literature, several correlations have been proposed for bubble size pre-diction in bubble columns. However, these correlations fail to predict bubble di-ameter over a wide range of conditions. Based on a data bank of around 230 measurements collected from the open literature, a correlation for bubble sizes in the homogenous region in bubble columns was derived using Artificial Neural Network (ANN) modeling. The bubble diameter was found to be a function of six parameters: gas velocity, column diameter, diameter of orifice, liquid density, liquid viscosity and liquid surface tension. Statistical analysis showed that the proposed correlation has an Average Absolute Relative Error (AARE) of 7.3% and correlation coefficient of 92.2%. A comparison with selected correlations in the literature showed that the developed ANN correlation noticeably improved the prediction of bubble sizes. The developed correlation also shows better prediction over a wide range of operation parameters in bubble columns.