Aim of the present study was to find out the chemopreventive
efficacy of Piper longum, a plant having diverse medicinal properties,
in 7,12-dimethyl benz (a) anthracene (DMBA) induced oral carcinogenesis.
The mechanistic pathway for its chemopreventive potential was analysed
by measuring lipid peroxidation and antioxidants status in DMBA induced
oral cancer. DMBA painting in hamster buccal pouch three times per week
for 14 weeks resulted in well developed, well differentiated squamous
cell carcinoma. Elevated lipid peroxidation and decline in antioxidants
were noticed in tumor bearing hamsters as compared to control animals.
Oral administration of ethanolic extract of Piper longum dried
fruits (PLEFet) on alternate days to DMBA painting significantly prevented
the tumor incidence, volume and burden and restored the status of lipid
peroxidation and antioxidants in DMBA painted hamsters. Our results indicate
that the dried fruits of P. longum has suppressing effects on cell
proliferation, which is probably due to its antilipid peroxidative and
antioxidative potential during DMBA induced oral carcinogenesis.