Tomato is an important vegetable and a cheap source of vitamin C, thus ranks number one in their contribution to diet. However, the yield in Nigeria, especially in Southern eastern part is very low when compared to other parts. There is widespread of soil degradation, which is brought about by loss of organic matter, which consequently results in soil acidity, nutrient imbalance and low crop yields. This study therefore focused on the effect of application of different rates of poultry manure on the growth and yield of tomato (Lycopersicum esculentum Mill). The study was investigated at the Teaching and Research Farm of Department of Agricultural Education, Nwafor Orizu College of Education Nsugbe, Anambra State during 2013 cropping season. The treatment rates were 0.0, 5.0, 7.5 and 10.0 t ha1 poultry manure. The experimental design was a randomized complete block design replicated four times. The parameters measured were number of branches per plant, number of trusses, flowers and fruits per plant, plant height and fruit and seed weight. The result showed that 10 t ha1 poultry manure performed better than others in both growth and yield parameter while the plants in control plots gave the least performance. It is therefore recommended that 10 t ha1 rate of poultry manure should be applied to tomato for optimum growth and yield in the study area.