Heterocyclic compounds like 8-hydroxyquinoline (8HQ) and derivatives
have been found in natural products and therapeutics. Herein 8HQ and metal complexes
of 8HQ-5-substituted (X) uracils, X = I, NO2 (1-6) were investigated
for their antimicrobial potency. The complexes 1-6 exhibited growth inhibition
against many strains of gram-positive and gram-negative bacteria with minimum
inhibitory concentrations (MICs) of 575.71-718.76 μM. The investigated
compound 8HQ was shown to be a very strong antimicrobial agent with the MIC
of 27.58 μM that comparable to ampicillin (MIC 26.93 μM), the reference
drug. The activity of 8HQ mostly was observed for resistant pathogens, gram-
positive bacteria e.g. Staphylococcus aureus, Enterococcus faecalis
and diploid fungus, Candida albicans. The findings reveal 8HQ as the
very potent antimicrobial agent and a series of 8HQ transition metal complexes
as novel antimicrobials as well as the applications of 8HQ for the design and
synthesis of new and potential therapeutic lead compounds.
S. Srisung, T. Suksrichavalit, S. Prachayasittikul, S. Ruchirawat and V. Prachayasittikul, 2013. Antimicrobial Activity of 8-Hydroxyquinoline and Transition Metal Complexes. International Journal of Pharmacology, 9: 170-175.