Abstract:
The natural products served as important sources of medicines now a day increasing, as they possess the therapeutic activity. Therefore, the present study was carried out to evaluate the analgesic activity of the petroleum ether and methanol extract of Abelmoschus manihot (Malvaceae) leaves using hot plate and tail immersion model. The air-dried, powdered leaves (1000 g) were extracted over Soxhlet with petroleum ether and methanol. The crude dried petroleum ether (10 g) and methanol (25 g) extracts was prepared at the doses of 100, 200 and 400 mg kg-1 and evaluated for analgesic activity using the hot plate and tail immersion test. The results obtained indicate that the extracts possessed significant (p<0.05, p<0.01) analgesic activity, which was found to be dose-dependent. A significant inhibition in pain threshold in hot-plate test was exhibited. However, in flick test, highest analgesic activity was observed only with 400 mg kg-1 dose as compared with the standard drug. This study showed that the petroleum ether and methanol extracts of Abelmoschus manihot leaves possess potential pharmacological active constituents responsible for inhibition of the analgesic effect.
S. Jain Pritam, A. Todarwal Amol, B. Bari Sanjay and J. Surana Sanjay, 2011. Analgesic Activity of Abelmoschus manihot Extracts. International Journal of Pharmacology, 7: 716-720.
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