The effect of a single dose pre-treatment with chloramphenicol at 50 mg kg-1 given intramuscularly on xylazine sedation was evaluated on 6 Sokoto Red goats weighing 11-14 kg. The duration of xylazine sedation after xylazine administration at 0.2 mg kg-1 IM alone was 83.16±10.95 min (control), as against 129±1.78 and 157.83±4.99 min for the other two pre-treatments with chloramphenicol, respectively. There was a significant (p<0.05) decrease in the haemoglobin concentration for all treatments while a significant increase in the white blood cells count was observed for all treatments. Irrespective of weight variation, the goats in all exhibited the same clinical signs. It can be deduced from this research that chloramphenicol pre-treatment may prolong the duration of action of xylazine sedation.
M. Gweba, K. I. Onifade and O. O. Faleke, 2009. Effect of Xylazine Sedation on Some Haematological Indices after Chloramphenicol Pre-Treatment in Sokoto Red Goats. International Journal of Pharmacology, 5: 76-80.