The aim of this experiment was to find
the appropriate dosage at which Testosterone Propionate (TP) is genotoxic
enough to cause significant chromosome damage. TP was examined at 10,
20 and 40 μM, respectively and found to be significantly genotoxic
at 20 and 40 μM, only in the presence of metabolic activation. Epicatechin
Gallate (ECG) proved to be an effective antioxidant by reducing genotoxic
damage. The results imply a strong genotoxic effect of TP in vitro
on human lymphocytes and also a relevant antigenotoxic role of ECG in
ameliorating steroid induced genotoxicity.
Tanveer Beg, Yasir Hasan Siddique, Gulshan Ara, Jyoti Gupta and Mohammad Afzal, 2008. Antioxidant Effect of ECG on Testosterone Propionate Induced Chromosome Damage. International Journal of Pharmacology, 4: 258-263.