To examine a potential role of flaxseed in postmenopausal
bone loss, 30 wistar rats were divided randomly into 5 groups and given
a basal diets and supplemented one with flaxseed for 12 weeks. The treatments
groups were as followed: sham operated groups+basal diet, ovariectomized
(OVX) + basal diet, OVX + 5% of flaxseed supplementation (FS), OVX+ 50%
(FS), OVX+100% (FS). An increase ALP activity and urinary excretion of
phosphorus and calcium were observed in OVX groups. The serum phosphorus
and calcium were significantly lowered in OVX group than the sham group.
The treatment with FS did not improve the later parameters at 50 and 100%
of supplementations, while a decreased urinary excretion of phosphorus
and calcium were noted. The administration of whole flaxseed at 5, 50
and 100% of supplementation, did not appear to have such as beneficial
effect on the bone mineral density of femurs of treated animals. These
findings provide evidence that dietary supplementation with flaxseed can
prevent postmenopausal bone loss.
Samira Boulbaroud, Asma Arfaoui, Chahine Abdelkrim, Abdelhalem Mesfioui, Ali Ouichou and Aboubaker El Hessni, 2008. Does Flaxseed Uptake Reverse Induced-Bone Loss in Ovariectomized Rats?. International Journal of Osteoporosis and Metabolic Disorders, 1: 24-30.