Subscribe Now Subscribe Today
Science Alert Home Journals at Science Alert For Authors For Subscribers Contact Us
   
International Journal of Cancer Research
  Year: 2012 | Volume: 8 | Issue: 3 | Page No.: 95-104
DOI: 10.3923/ijcr.2012.95.104
Selected Cruciferous Vegetables and their Effects on Azoxymethane (AOM) Induced Aberrant Crypt Foci
R.L. Miller-Cebert, J. Boateng, L. Shackelford, E. Cebert, L.T. Walker and M. Verghese

Abstract:
Cruciferous vegetables contain naturally occurring substances that are beneficial to health. The purpose of this study was to investigate the effects of selected cruciferous vegetables (Collard Green (CG), cabbage (CB), turnip green (TG) and canola green (CN) on Azoxymethane (AOM)-induced Aberrant Crypt Foci (ACF) on Fisher 344 male rats. Thirty-six rats were randomly assigned to 9 groups (n = 4). The control group was fed AIN-93G diet and the other eight groups were fed AIN-93G along with the selected vegetables at 5 and 10%. The rats were administered subcutaneous injections of AOM at 7 and 8 weeks of age at 16 mg kg-1 body weight. At 17 weeks of age, rats were killed by CO2 asphyxiation. Total ACF numbers in rats fed CB, TG, CG and CN at 5% were 55, 41, 47 and 59, while at the 10% level, ACF numbers were 54, 63, 54 and 46, respectively. Total ACF in rats fed 5 and 10% cruciferous vegetables were significantly (p<0.05) lower (41-63) than rats fed the control diet (151). Findings indicate that cruciferous vegetables, including canola reduced the incidence of ACF and could potentially be used as a dietary chemopreventive agent against colon cancer.
 [Fulltext PDF]   [Fulltext HTML]   [XML: Abstract + References]   [References]   [View Citation]  [Report Citation]
 RELATED ARTICLES:
  •    Canola and Mustard Seeds/Sprouts Reduce the Formation of Aberrant Crypt Foci in Azoxymethane-Induced Colon Cancer in Fisher 344 Male Rats
  •    Inhibitory Effects of Feeding Selected Levels of Peanuts on Azoxymethane-Induced Aberrant Crypt Foci in Male Fisher 344 Rats
  •    Alterations in Plasma Lipid Peroxidation and Erythrocyte Superoxide Dismutase and Glutathione Peroxidase Enzyme Activities During Storage of Blood
  •    Feeding Almonds and Pecans Reduced Development of Azoxymethane Induced Precancerous Lesions
How to cite this article:

R.L. Miller-Cebert, J. Boateng, L. Shackelford, E. Cebert, L.T. Walker and M. Verghese, 2012. Selected Cruciferous Vegetables and their Effects on Azoxymethane (AOM) Induced Aberrant Crypt Foci. International Journal of Cancer Research, 8: 95-104.

DOI: 10.3923/ijcr.2012.95.104

URL: http://scialert.net/abstract/?doi=ijcr.2012.95.104

 
COMMENT ON THIS PAPER
.
 
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 
 
 
 
 

                 home       |       journals        |       for authors       |       for subscribers       |       asci
          © Science Alert. All Rights Reserved