Endophytic Streptomycetes are the most exploited group in the medicinal and agro based industries. In this review, we correlated recently identified its bioactive compounds with plant chemical structures. Booming the global warm is the important problem to increase the alternative research initiatives for green chemicals. During long genetic co-evaluation with plants Streptomycetes have created novel and interesting chemistry. Their ability to produce plant related chemicals has increased its importance. It also reduces the need of harvesting plants for drug. Specific approaches from ethanobotanical valued plants with medicinal applications could be the key to isolating bioactive compound producing strains.