Localization and distribution of inorganic constituents, organic constituents and enzymes and their functional significance in the histological sections of an unaltered liver of the snow trout, Schizothorax curvifrons has been studied by adopting various histochemical techniques with the objectives that this study will set a solid platform for further studies in relation to pollution, stress conditions in aquaculture, natural and polluted environments and pathobiology of teleost liver. Histochemical analysis reveals that the cytoplasm of the hepatocytes depict strong positive reaction for iron and reacts negatively to calcium. The polyhedral hepatocytes are characterized by high concentration of proteins, being perinuclear or peripheral in position. The centrally placed nuclei of the hepatocytes exhibit intense reaction for DNA whereas their cytoplasmic part is observed to be glycogen positive and the lipoid particles are also observed to be uniformly distributed throughout the perilobular and centrolobular regions of the liver, however, the nuclei of the hepatocytes are totally sudanophobic. The hepatic cytoplasm of Schizothorax curvifrons is observed to be rich in alkaline and acid phosphatase activities, the activity of alkaline phosphatase being stronger in the perilobular zone and that of acid phosphatase being restricted to the cell membrane and around the nucleus. Adenosine triphosphatase (ATPase) activity in the cytoplasm and nuclei of the hepatocytes is higher in the centrolobular region, on the other hand greater activity of lipase in the perilobular zone of the liver of Schizothorax curvifrons is found to be confined to the cytoplasm around the nuclei of the hepatocytes.