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International Journal of Biological Chemistry
  Year: 2011 | Volume: 5 | Issue: 1 | Page No.: 37-45
DOI: 10.3923/ijbc.2011.37.45
Synthesis and Antibacterial Activity of Thioureido Amide of Fluoroquinolone
N.B. Patel, S.D. Patel, J.N. Patel, J.C. Patel and Y.S. Gorgamwala

Abstract:
We have synthesized thioureido amide of fluoroquinolone to study the variation in biological activity. All the compounds were synthesized from simple condensation of acid chloride with phenyl thiourea to give thioureido amides, which further condensed with substituted piperazines, structure of the compounds were conformed from IR and 1H-NMR spectra and elemental analysis. All the compounds evaluated for antibacterial activity against S. aureus, B. subtilis, E. coli, P. aeruginosa using cup-plate method. Significant improvement in biological activity was observed.
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How to cite this article:

N.B. Patel, S.D. Patel, J.N. Patel, J.C. Patel and Y.S. Gorgamwala, 2011. Synthesis and Antibacterial Activity of Thioureido Amide of Fluoroquinolone. International Journal of Biological Chemistry, 5: 37-45.

DOI: 10.3923/ijbc.2011.37.45

URL: http://scialert.net/abstract/?doi=ijbc.2011.37.45

 
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