Abstract: Artemisia dracunculus is an appetizer plant, its anti fungal and anti tumor properties has been demonstrated previously, but there are a few studies on its antibacterial effects. The aim of the present study was the evaluation of the antibacterial activity of Artemisia dracunculus essential oil on burn isolates of Acinetobacter baumannii. Forty eight isolates of Acinetobacter baumannii were collected from the burn wound infections. Muller-Hinton Broth was supplemented with 0.002% (v/v) tween 80. Serial doubling dilutions of Artemisia dracunculus essential oil over the range 0.03-25% were prepared. 1.5x106 inoculums of the isolates were added to each concentration. Antibacterial activity was measured by determining Minimum Inhibitory Concentration and Minimum Bactericidal Concentration of isolates to Artemisia dracunculus essential oil. The susceptibilities of isolates to different antibiotics were tested using agar disc diffusion method. The rates of resistance were determined to antibiotics as follows: gentamicin 70.8%, ticarcillin 93.7%, ceftizoxime 75%, co-trimoxazole 79.1%, amikacin 52%, carbenicillin 93.7%, cefalotin 60.4%, cefazolin 100%, piperacillin 88.9%, imipenem 14.6%, kanamycin 95.8% and ofloxacin 95.8%. 14.5% of isolates were sensitive to all tested concentrations of Artemisia dracunculus essential oil. For the 10.4, 20.8 and 54.1% of remaining isolates Minimum Inhibitory Concentration and Minimum Bactericidal Concentration values were 1.56x10-2, 7.8x10-2 and -3.9x10-3, respectively. These results suggest the potential use of the Artemisia dracunculus essential oil for the control of Multi-drug resistant Acinetobacter baumannii infections.
N.H. Jazani, M. Zartoshti, H. Babazadeh and N. Ali-daiee, 2011. Antibacterial Effects of Artemisia dracunculus Essential Oil on Multi-drug Resistant Isolates of Acinetobacter baumannii. Bacteriology Journal, 1: 31-36.