The present study was designed to investigate the hypoglycemic
and hypolipidemic activity of aqueous extract of Monascus fermented
Indian variety rice in high cholesterol fed-streptozotocin-induced diabetic
rats. Wister rats were fed with high cholesterol diet for 2 weeks prior
to intra-peritoneal injection with streptozotocin (50 mg kg-1).
The Indian variety rice IR-532-E-576 was fermented with Monascus purpureus
for 10 days and sterilized. Aqueous extract of the fermented rice at two
dose levels showed a significant decrease in fasting blood glucose level.
The total cholesterol and triglycerides were also significantly reduced
where as the HDL cholesterol levels were significantly increased, which
confirmed the potent anti-diabetic property of the Monascus purpureus
fermented rice in diabetic rats, which may be due to presence of statins.
A. Rajasekaran, M. Kalaivani and R. Sabitha, 2009. Anti-Diabetic Activity of Aqueous Extract of Monascus purpureus Fermented Rice in High Cholesterol Diet Fed-Streptozotocin-Induced Diabetic Rats. Asian Journal of Scientific Research, 2: 180-189.