Methanolic, chloroform and aqueous extracts of 11 medicinal plants used in folklore medicine in Saudi Arabia, were investigated for in vitro activity against four pathogenic fungi. The extracts at concentration of 0.5 mL plate-1 showed varying degrees of total inhibition of fungal growth. Extracts from Salvadora persica and Vigna fragrans showed the highest activity, followed by Peganum harmala and Withania somnifera, while Polycarpaea corymbosa demonstrated the least activity, when compared to 25 μg mL-1 Clotrimazole control antibiotic. The fungal strains tested differed significantly in their susceptibility to plant extracts, with complete inhibition in Aspergillus fumigatus and Candida albicans. The plants which exhibited a marked antifungal activity were shown to be rich in alkaloids, flavanoids, tannins and glycosides. These results support the traditional use of these plants in the treatment of some fungal infections.