Babacar Faye
Laboratory of Molecular Biology, Hospital Military De Ouakam, Dakar, Senegal
LiveDNA: 221.38653
Mame Diarra Bousso Lam
Laboratory of Molecular Biology, Hospital Military De Ouakam, Dakar, Senegal
Ismail Barkire
Service of Internal Medicine, Hospital Military De Ouakam, Dakar, Senegal
Micailou Magassouba
National Alliance of Communities for Health, Dakar, Senegal
Hameth Sarr
Laboratory of Molecular Biology, Hospital Military De Ouakam, Dakar, Senegal
Aissatou Ngom
Service of Pediatric, Hospital Military De Ouakam, Dakar, Senegal
Alioune Dieye
Service of Immunology, Department of Pharmacy, Faculty of Medicine, Pharmacy and Odonto-Stomatology,
University Cheikh Anta Diop, Dakar, Senegal
Background and Objective: Antiretroviral treatment is a powerful means of reducing the risk of HIV transmission. Several observational studies have demonstrated a reduction in the risk of sexual transmission of HIV in people on ARV treatment and the main objective of antiretroviral treatment is to prevent progression to AIDS and death. Thus, the objective of this study was to evaluate the efficacy of the AZT+3TC+NVP therapeutic regimen in the treatment of HIV infection. Materials and Methods: This is a retrospective study of the treatment of HIV-1 seropositive patients. During this study, 445 patients were included and followed in the molecular biology laboratory of the HIV/AIDS program from 2014 to 2021. All plasma samples were from HIV-1-positive patients. Plasma viral load tests were performed on Abbott Real-Time HIV-1® (m2000sp/rt) and COBAS®AmpliPrep TaqMan® (Roche) v.2.0. As p<0.05 was considered statistically significant. Results: The median age was 33 years, women represented 71.2% of patients. Viral load was undetectable in 6.7% and 73.5% of patients at 6 and 12 months, respectively. At 12 months, virological suppression was 80.5% in women and 56.3% in men (p=0.01). At 12 months, patients aged had significantly greater viral suppression than the youngest (p=0.001). At the 18 months, 80.2% of patients had a suppressed viral load and 13% of patients had virologic failure. Conclusion: The AZT+3TC+NVP was effective in terms of virological suppression. Viral suppression was associated with sex and age at 12 months of treatment. Therapeutic failure was relatively low. This treatment is still effective and less expensive, which is why it is so interesting for countries with limited resources.
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How to cite this article
Babacar Faye, Mame Diarra Bousso Lam, Ismail Barkire, Micailou Magassouba, Hameth Sarr, Aissatou Ngom and Alioune Dieye, 2023. Molecular Evaluation of the Efficacy of the AZT+3TC+NVP Therapeutic Regimen in the Treatment of HIV-1 Patients in Senegal. American Journal of Biochemistry and Molecular Biology, 13: 36-41.
DOI: 10.3923/ajbmb.2023.36.41
URL: https://scialert.net/abstract/?doi=ajbmb.2023.36.41
DOI: 10.3923/ajbmb.2023.36.41
URL: https://scialert.net/abstract/?doi=ajbmb.2023.36.41