Subscribe Now Subscribe Today
 
FOLLOW US:     Facebook     Twitter
   
Asian Journal of Biochemistry
  Year: 2009 | Volume: 4 | Issue: 4 | Page No.: 133-139
DOI: 10.3923/ajb.2009.133.139
Protective Effect of Squalene on Endogenous Antioxidant Vitamins in Experimentally Induced Myocardial Infarction in Rats
K.H.S. Farvin, A. Surendraraj and R. Anandan

Abstract:
In the present study an attempt has been made to assess the cardioprotective effect of squalene on isoprenaline-induced myocardial infarction in male albino rats with respect to changes in the levels of endogenous antioxidant vitamins in heart tissue. Levels of endogenous antioxidants such as ascorbic acid, α-tocopherol and endogenous squalene content in heart tissue were determined. Significant (p<0.001) reduction was observed in the levels of ascorbic acid, α-tocopherol and endogenous squalene content in the heart tissue of isoprenaline administered rats compared to normal control rats. It is worth noting that, the prior administration of squalene at 2% level along with feed for 45 days significantly (p<0.001) reduced the isoprenaline-induced decline in the levels of these vitamins and restored the membrane bound squalene content at near normal. The results of the present study indicates that the cardioprotective effect of squalene might be ascribable to its antioxidant property thereby sharing the responsibility of these antioxidant vitamins in counteraction of free radicals generated during isoprenaline-induced oxidative stress.
 [Fulltext PDF]   [Fulltext HTML]   [XML: Abstract + References]   [References]   [Report Citation]
 RELATED ARTICLES:
  •    Effects of Deep-Fat Frying using Canola Oil, Soya Oil and Vegetable Oil on the Proximate, Vitamins and Mineral Contents of Unripe Plantain (Musa x paradisiaca)
  •    Cardioprotective Effect of a Medicinal Mushroom, Ganoderma lucidum Against Adriamycin Induced Toxicity
  •    Impact of Three Cooking Methods (Steaming, Roasting on Charcoal and Frying) on the β-Carotene and Vitamin C Contents of Plantain and Sweet Potato
  •    Protective Effects of Lagenaria siceraria (Molina) Fruit Juice in Isoproterenol Induced Myocardial Infarction
How to cite this article:

K.H.S. Farvin, A. Surendraraj and R. Anandan, 2009. Protective Effect of Squalene on Endogenous Antioxidant Vitamins in Experimentally Induced Myocardial Infarction in Rats. Asian Journal of Biochemistry, 4: 133-139.

DOI: 10.3923/ajb.2009.133.139

URL: http://scialert.net/abstract/?doi=ajb.2009.133.139

 
COMMENT ON THIS PAPER
.