This study was carried out to assess the status and
correlation between lipid peroxidation and antioxidant status in CRF patients.
Forty predialytic CRF patients, of either sex and age >25 years with
serum creatinine levels >3.0 mg dL-1 and forty healthy controls
were included in the study. Serum MDA levels were estimated by colorimetric
method and Total Antioxidant Capacity (TAC) was estimated by Ferric Reducing
Antioxidant Power (FRAP) assay. It was observed that statistically significant
increase in MDA levels in CRF patients correlating positively with creatinine
and BUN and significant decrease in TAC in CRF patients correlating negatively
with creatinine and BUN. Significant negative correlation was observed
between MDA and TAC in CRF patients which is suggestive of increased lipid
peroxidation and depletion of antioxidants causing an imbalance between
OFR and TAC leading to progressive renal injury. This study would be beneficial
to identify patients with increased risk of CRF and also for monitoring
and optimization of antioxidant therapy.