Abstract:
The effect of ethanolic leaf extract from Cassia hirsuta (L.) on the DNA profile of some selected pathogenic microorganisms were investigated using PCR-RAPD analysis to generate DNA fingerprints. The change in molecular configuration of organisms with and without extract shows a wide disparity between the sensitive and the resistant organisms. Thus, this study demonstrates that some of the organisms are susceptible to the antimicrobial activity of Cassia hirsuta extract while some are resistant. The mechanism of action of the extract or other antimicrobial agent on these organisms is due to alteration on the genome and the extract is mutagenic on the susceptible organisms.
M.K. Oladunmoye, F.C. Adetuyi and F.A. Akinyosoye, 2007. Effect of Cassia hirsuta (L.) Extract on DNA Profile of Some Microorganisms
. Asian Journal of Biochemistry, 2: 142-146.
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