This preliminary study examined the efficacy of serum fructosamine and Random Blood Sugar (RBG) for the screening of Gestational Diabetes Mellitus (GDM). Venous blood samples from 32 pregnant women were analyzed for serum fructosamine and RBG. The actual fructosamine levels were corrected for serum protein (c-fructosamine) for more precise presentation. Subjects with RBG > 7.8 mmol L-1 were assigned to hyperglycemic group. The results showed a significant correlation between RBG and c-fructosamine (Pearson correlation = 0.53, p<0.01). Out of 32 subjects, 6 (18.75%) were found to be hyperglycemic (RBG >7.8 mmol L-1). The levels of both RBG (9.916±0.82 versus 5.019±0.231 mmol L-1, p<0.0001) and c-fructosamine (2.541±0.132 versus 2.251±0.057 mmol L-1, p<0.05) were significantly higher in hyperglycemic subjects as compared to normal pregnant women. One patient with normal RBG showed above normal c-fructosamine (3.125 % false positive), whereas 3 patients with hyperglycemia had normal c-fructosamine (9.375% false negative). The findings of this preliminary study clearly indicate that the paired values of fructosamine and RBG could help in filtering high-risk individuals prior to OGTT, thereby avoiding cumbersome OGTT for identification of GDM in a large number of patients.
Haseeb A. Khan , Abdurrahman S. Alhomida , Samia H. Sobki and Shaukat A. Khan , 2006. Relevance of Serum Fructosamine and Random Blood Glucose for the Screening of Gestational Diabetes Mellitus. Asian Journal of Biochemistry, 1: 41-46.