An alternative coccidiosis treatment in response to the side effects of routinely use of conventional anticoccidial drugs was investigated on 600 E. tenella experimentally infected day-old Harco chicks in a factorial design at the Benin Agronomic Faculty Research Station. The effect ofCarica papaya, Vernonia amygdalina and Azadiratcha indica dry leaf powder in the conventional feed (15% incorporation) was evaluated. C. papaya, the most ingested plant reduced the infected untreated control OPG down to 53% and V. amygdalina, down to 35%, even though it was less ingested than C. papaya. However, this reduction constituted 56 and 37% (C. papaya and V. amygdalina) of the conventional coccidiostatic effectiveness. The OPG reduction might be ascribed on the hand to the bitterness and on the other to the chemical compound, papaine and Vernoside. A. indica was less ingested due to it higher bitterness, repellency and toxicity. Consequently it exalted the disease and produce more oocysts than the control group. The plant OPG reduction mechanism and the accepted leaf powder dose need to be investigated.